Augmentin Dose Calculator

SETELDOC • MALAYSIAN PRIMARY CARE

Augmentin Dose Calculator
for Children

Paediatric amoxicillin/clavulanate dosing for acute otitis media using the current Malaysian National Antimicrobial Guideline.

✓ AOM-specific ✓ 7:1 & 14:1 formulations ✓ Amoxicillin-component dosing
DOSE CALCULATOR

Amoxicillin / clavulanate

Acute otitis media
kg
QUICK REFERENCE

NAG paediatric AOM dosing

Dose is based on the amoxicillin component.

Formulation ratio Amoxicillin dose Frequency Maximum
14:1 80–90 mg/kg/day BD 3 g/day
7:1 40–50 mg/kg/day BD 3 g/day

The calculator uses 90 mg/kg/day for 14:1 and 50 mg/kg/day for 7:1 — the upper ends of the exact dose ranges stated by NAG. NAG gives 7–10 days below 2 years and 5–7 days above 2 years; SetelDoc displays 7 days, which falls within both published ranges.

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CLINICAL NOTES

Source-specific notes

AOM scenario in NAG NAG places amoxicillin/clavulanate under the AOM scenario described as clinical failure, history of amoxicillin use in the last 30 days and concurrent purulent conjunctivitis.
14:1 formulation NAG recommends 80–90 mg/kg/day of the amoxicillin component in 2 divided doses, maximum 3 g/day.
7:1 formulation NAG recommends 40–50 mg/kg/day of the amoxicillin component in 2 divided doses, maximum 3 g/day.
Treatment duration NAG lists 7–10 days for children below 2 years and 5–7 days for children above 2 years. SetelDoc displays a fixed 7-day course because 7 days is within both published ranges.
NAG comment on 14:1 NAG states that 90 mg/kg/day amoxicillin with 6.4 mg/kg/day clavulanate gives a 14:1 ratio in 2 divided doses and is less likely to cause diarrhoea than other amoxicillin/clavulanate preparations.
NAG comment on 7:1 NAG states that amoxicillin/clavulanate 40–50 mg/kg/day may not be adequate for AOM caused by penicillin-nonsusceptible S. pneumoniae.
228 / 457 mg per 5 mL The current Malaysian NPRA Augmentin product insert states that 228 mg/5 mL contains 200 mg amoxicillin + 28.5 mg clavulanate, while 457 mg/5 mL contains 400 mg amoxicillin + 57 mg clavulanate.
642.9 mg per 5 mL The Ministry of Health Malaysia Drug Code lists Augmentin ES 642.9 mg/5 mL. GSK product information states that this strength contains 600 mg amoxicillin + 42.9 mg clavulanic acid per 5 mL, giving the 14:1 formulation used by the calculator.
COMMON QUESTIONS

Augmentin paediatric-dose FAQ

What dose does NAG use for 14:1 Augmentin in paediatric AOM?

NAG gives 80–90 mg/kg/day based on the amoxicillin component, orally in 2 divided doses, with a maximum amoxicillin dose of 3 g/day.

What dose does NAG use for 7:1 Augmentin in paediatric AOM?

NAG gives 40–50 mg/kg/day based on the amoxicillin component, orally in 2 divided doses, with a maximum amoxicillin dose of 3 g/day.

Why does SetelDoc calculate 90 mg/kg/day or 50 mg/kg/day?

Those are the upper ends of the respective NAG ranges: 80–90 mg/kg/day for 14:1 and 40–50 mg/kg/day for 7:1. This is a SetelDoc calculator choice and is labelled separately from the full NAG ranges.

How long is treatment for AOM?

Current NAG lists 7–10 days below 2 years and 5–7 days above 2 years. SetelDoc displays 7 days because it falls within both published ranges.

Are 228 mg/5 mL and 457 mg/5 mL the same ratio?

Yes. The current Malaysian NPRA Augmentin product insert states 228 mg/5 mL contains 200 mg amoxicillin + 28.5 mg clavulanate, and 457 mg/5 mL contains 400 mg amoxicillin + 57 mg clavulanate. Both are approximately 7:1.

Clinical references

  1. Ministry of Health Malaysia — National Antimicrobial Guideline: Paediatric Otorhinolaryngology Infections — AOM indication context, 7:1 and 14:1 dose ranges, maximum dose and treatment duration.
  2. NPRA — Malaysian Augmentin Suspension Product Insert — composition of 228 mg/5 mL and 457 mg/5 mL suspensions.
  3. Ministry of Health Malaysia — Malaysia Drug Code — listing of Augmentin ES 642.9 mg/5 mL.
  4. GSK — Augmentin ES Product Information — composition of 642.9 mg/5 mL as amoxicillin 600 mg + clavulanic acid 42.9 mg per 5 mL.

For healthcare professionals. This page is restricted to the paediatric acute otitis media regimen described above. Do not apply this calculator to a different infection unless the dosing source for that indication is separately verified.

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