SETELDOC • MALAYSIAN PRIMARY CARE

Domperidone Dose Calculator

Quick oral domperidone dosing for nausea and vomiting, with mg and mL per dose using 5 mg/5 mL suspension.

✓ Nausea + vomiting ✓ 5 mg/5 mL suspension ✓ Cardiac safety reminders

Use this domperidone dose calculator to calculate oral dosing and suspension volume for appropriate patients with nausea or vomiting.

QUICK CALCULATOR

Domperidone oral dose

Nausea / vomiting

Important paediatric restriction: do not use domperidone in infants and children younger than 12 years who weigh less than 35 kg.

Cardiac safety: avoid domperidone in patients with known QT prolongation, significant electrolyte disturbance, underlying cardiac disease, or concomitant QT-prolonging medicines or potent CYP3A4 inhibitors.

Age

Weight (kg)

Frequency

Suspension concentration

5 mg/5 mL Oral suspension

QUICK REFERENCE

Domperidone oral dosing

Malaysian age- and weight-based dosing reference.

Patient	Dose	Frequency	Maximum/day
<12 years AND <35 kg	Do not use	—	—
<12 years AND ≥35 kg	10 mg 10 mL of 5 mg/5 mL	TDS–QID	40 mg/day
≥12 years AND <35 kg	0.25 mg/kg/dose	TDS–QID	35 mg/day
≥12 years AND ≥35 kg	10 mg 10 mL of 5 mg/5 mL	TDS–QID	40 mg/day

Formulation: all suspension volumes on this page use domperidone 5 mg/5 mL.

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Paediatric Dose Calculator Demo

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Weight (kg)

Sample preview only. Full access includes the complete medicine list, drug-specific age limits and clinical notes.

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CARDIAC SAFETY

Before prescribing domperidone

QT prolongation Avoid domperidone in patients with known prolongation of cardiac conduction intervals.

Electrolytes Significant electrolyte disturbances increase cardiac risk.

Cardiac disease Avoid in patients with significant underlying cardiac disease.

QT-prolonging drugs Avoid concomitant medicines that prolong the QT interval.

CYP3A4 inhibitors Potent CYP3A4 inhibitors can increase domperidone exposure. Domperidone with clarithromycin is contraindicated.

Duration Use the lowest effective dose for the shortest duration. The usual maximum treatment period should not exceed 1 week.

Lactation This calculator is not intended for off-label lactation stimulation.

CLINICAL USE

Treat the cause of nausea and vomiting

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Rehydration first

In gastroenteritis, assess dehydration and prioritise oral or intravenous rehydration as clinically appropriate.

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Look for the cause

Consider infection, medication effects, pregnancy, gastrointestinal obstruction, intracranial pathology, metabolic disease and other relevant differentials.

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Escalate red flags

Severe dehydration, haematemesis, bilious vomiting, peritonism, altered consciousness, shock or persistent unexplained vomiting require further assessment.

COMMON QUESTIONS

Domperidone FAQ

Can domperidone be used in a child younger than 12 years?

Domperidone should not be used in children younger than 12 years who weigh less than 35 kg. For a child younger than 12 years who weighs at least 35 kg, the Malaysian formulary lists a fixed 10 mg dose.

What dose is used at ≥12 years but below 35 kg?

The calculator uses 0.25 mg/kg per dose, given three to four times daily, with a maximum total dose of 35 mg/day.

What suspension concentration does this calculator use?

Every mL calculation on this page uses domperidone 5 mg/5 mL suspension.

How long should domperidone be prescribed?

Use the lowest effective dose for the shortest duration. The usual maximum treatment period should not exceed one week.

Why is clarithromycin important?

Clarithromycin can increase domperidone exposure through CYP3A4 inhibition and also has QT-prolonging properties. Concomitant use is contraindicated.

Clinical references

Ministry of Health Malaysia — Formulari Ubat KKM: Domperidone oral suspension and tablet.
National Pharmaceutical Regulatory Agency Malaysia — restriction of domperidone use in paediatric patients younger than 12 years.
National Pharmaceutical Regulatory Agency Malaysia — domperidone and clarithromycin interaction and QT prolongation.

For healthcare professionals. Use clinical judgement and review age, weight, cardiac risk, electrolyte status, interacting medicines and current product information before prescribing.