Tamiflu (Oseltamivir)
Prophylaxis Dose
Post-exposure oseltamivir dosing after close contact with influenza, based on the current Malaysian Tamiflu NPRA.
This page summarises post-exposure prophylaxis dosing from the Malaysian Tamiflu product insert for patients aged 1 year and older and within the stated weight bands. Start prophylaxis as soon as possible within 2 days of exposure.
Malaysian Tamiflu post-exposure prophylaxis
Start as soon as possible within 2 days of exposure.
| Patient | Dose | 60 mg/5 mL | Regimen |
|---|---|---|---|
| <1 year or <10 kg | Not included | — | Malaysian PI indication begins at ≥1 year and 10kg |
| 1–12 years 10–15 kg | 30 mg | 2.5 mL | OD × 10 days |
| 1–12 years >15–23 kg | 45 mg | 3.75 mL | OD × 10 days |
| 1–12 years >23–40 kg | 60 mg | 5 mL | OD × 10 days |
| 1–12 years >40 kg | 75 mg | 6.25 mL | OD × 10 days |
| ≥13 years / adult | 75 mg | 6.25 mL | OD × 10 days |
Renal impairment: do not use the standard regimen above without checking renal-adjusted prophylaxis dosing in adolescents and adults.
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Before prescribing prophylaxis
Tamiflu prophylaxis FAQ
When should post-exposure Tamiflu prophylaxis be started?
The current Malaysian Tamiflu product insert says therapy should begin as soon as possible within 2 days of exposure to an infected individual.
Why does this page use 10 days?
The current Malaysian NPRA-approved Tamiflu product insert gives a 10-day post-exposure prevention regimen. Some international guidance, including current CDC guidance, uses a different duration for routine chemoprophylaxis. This page deliberately follows the Malaysian product insert.
What is the prophylaxis dose for a 20 kg child?
For a child aged 1–12 years weighing more than 15 kg and up to 23 kg, the Malaysian product insert gives 45 mg OD × 10 days. With 60 mg/5 mL suspension, this is 3.75 mL OD × 10 days.
What is the adult post-exposure prophylaxis dose?
The Malaysian product insert gives 75 mg OD × 10 days for adolescents aged 13–17 years and adults. With 60 mg/5 mL suspension, 75 mg is equivalent to 6.25 mL.
Why is there no dose below 1 year or below 10 kg?
The Malaysian product-insert prophylaxis table begins at ≥1 year and 10 kg. This page does not extrapolate a dose outside those locally stated limits. Other international recommendations may differ.
Can I use this table for renal impairment?
No. Renal-adjusted oseltamivir prophylaxis uses different regimens in adolescents and adults and will be handled on a separate SetelDoc renal-dose page.
Why does FUKKM say not to use oseltamivir as prophylaxis?
FUKKM describes the KKM formulary indication and restriction for oseltamivir, while the Malaysian NPRA-approved Tamiflu product insert includes post-exposure prophylaxis. This page is based on the product insert and should not override local formulary or institutional prescribing policy.
Need a different Tamiflu regimen?
Clinical references
- Malaysian NPRA / QUEST3+ — Tamiflu product insert — post-exposure prophylaxis indication, dose bands, 10-day regimen and renal information.
- Ministry of Health Malaysia — FUKKM: Oseltamivir — current KKM formulary entry is for treatment and states not to use oseltamivir as prophylaxis.
- CDC — Influenza Antiviral Medications: Summary for Clinicians — international comparison; current routine chemoprophylaxis duration differs from the Malaysian product insert.
For healthcare professionals. This page supports but does not replace clinical judgement. Confirm exposure history, circulating influenza activity, renal function, local formulary restrictions and current product information before prescribing.